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doi: 10.1016/j.cmet.2012.04.022

May 28, 2026

This was consistent with a functional involvement of taste signaling in ghrelin release (55), although -gustducin is a non-specific downstream signaling molecule and, as discussed, an indirect interaction between brush cells and Gr cells is an alternative possibility

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Crew KD, Neugut AI

Even when a compound complies with Lipinski's rules, poor aqueous solubility can significantly limit its bioavailability