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GLP-1 therapies have demonstrated substantial weight-reduction benefits, with studies showing an average weight loss of 4.6 kg, a BMI reduction of 2.1 kg/m, and a decrease in waist circumference of 4.6 cm compared to placebo

In the STEP 1 trial, the 2.4 mg dose led to an average weight loss of 14.9% over 68 weeks

Schroeder, C., et al

They may feel strange, persistent symptoms for weeks and have no idea why

Additionally, the thyroid gland affects glucose metabolism and insulin sensitivity

GLP1 medications still help regulate appetite, but the rate of weight loss often slows as the body adapts and the initial response levels off, which can lead to a plateau