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Low levels of artificial light at night (5 lux) disrupt circadian rhythmicity with a reduction in Per1 and Per2 expression in the SCN, concurrent with altered expression of Bmal1, Per1, Per2 , and Cry1 in the liver of mice ( Night Shift Work, Travel, and Social Jet Lag Coinciding with the increase in light pollution as a result of industrialization, current society has deviated from 9 to 5 workdays

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thus, butyrate can decrease the cellular level of HO, which is a major indicator associated with ferroptosis (Hua et al., 2024)