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Nonetheless, as Waldmann explains, no one had managed to establish whether 'the cells that bound antigen actually then made antibodies to the antigen.' Waldmann illustrates the problem as follows, 'Let's say you took a B cell lymphocyte, and you looked to see whether it binds the antigen

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Chow-fed male C57BL/6J mice at 18 weeks of age were randomly assigned to receive once-daily s.c