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Any other effect can be considered as a pleiotropic, off-target effect, or in the case of unwanted actions, adverse effects ( Figure 1 )

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The number of self-reported current somatic diseases (including cardiometabolic, respiratory, musculoskeletal, digestive, neurological, endocrine diseases and cancer) for which participants received medical treatment was counted (coded as 0, 1, 2+) as a global marker of poor physical health

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