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2007 Aug;7(4):355-9

Excessive generation of ROS within ovarian, adipose, and hepatic tissues overpowers antioxidant defenses, leading to oxidative damage of lipids, proteins, and mitochondrial DNA ( Androgen excess exacerbates redox disequilibrium by promoting NADPH oxidase activity and mitochondrial ROS production, while simultaneously impairing follicular maturation and oocyte quality ( Figure 1 represents the involvement of redox imbalance and endocrine dysregulation in the ovary, leading to hyperandrogenism or PCOS

And, continuous yo-yo dieting has led to an even more unhealthy relationship with food

Neurochem J 14(2):127132

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This inflammatory milieu contributes to insulin resistance, cardiovascular disease, and potentially to joint inflammation and cartilage degradation