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The American Diabetes Association's 2024 Standards of Care explicitly flag the need for dose adjustments of diuretics when initiating GLP-1 receptor agonists in patients at risk for volume depletion [7]
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doi: 10.1172/JCI25764
Freeman, A
Its important to note, however, that GLP-1 therapy isnt a one-size-fits-all solution
Their GLP-1 Squared (sometimes written GLP-12) formulation combines both semaglutide and tirzepatide at individualized lower doses in a single compounded injection
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