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As one review summarizes, GLP-1s can lower libido in some people by affecting brain reward pathways, shifting hormones during weight loss, reducing energy and nutrition, causing GI discomfort, and interacting with emotional factors, and many notice improvement as the body adjusts or with dose and lifestyle changes
G.KoprivaS
These symptoms occur because GLP-1 compounds slow gastric emptying and alter digestive patterns, which can disrupt the gut microbiome and compromise digestive comfort
Red blood cells also show lower glutathione concentrations in older individuals
How does rapid weight loss from GLP-1 drugs compare to surgical weight loss procedures