[Epub ahead of print] The effect of Low Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental before-and-after Prescription Database Study
This offers several potential benefits: Avoids first-pass metabolism : Unlike swallowed medications that must pass through the liver, sublingual absorption delivers drugs directly to the bloodstream Bypasses stomach acid : GLP-1 peptides are degraded by digestive enzymes, so avoiding the stomach could improve stability Rich vascular network : The area under the tongue has extensive blood vessels that allow rapid absorption However, research on peptide delivery through oral mucosa reveals significant challenges: Peptides like semaglutide and tirzepatide have molecular weights around 4000 Da (compounds above 500 Da generally show poor permeability) Salivary and mucosal proteases degrade peptides before they can cross the epithelial barrier Continuous saliva production dilutes and washes away the medication Studies with insulin showed only 1-2% bioavailability via buccal/sublingual routes without absorption enhancers The key question: Do compounded ODT formulations overcome these barriers
And this week they published a report outlining their findings: Title: Diabetes medications and risk of Parkinsons disease: a cohort study of patients with diabetes Authors: Brauer R, Wei L, Ma T, Athauda D, Girges C, Vijiaratnam N, Auld G, Whittlesea C, Wong I, Foltynie T
Persistent nausea, reflux, constipation, rising resting heart rate, or broken sleep shows that the current dose has not settled
The findings hint at MT-II's potential to enhance sexual desire in women when used in conjunction with certain hormones [20]
Patients pursuing GLP-1 therapy often face a critical challenge: achieving weight loss while preserving lean muscle mass
