doi: 10.1016/j.lwt.2020.110366 148 OzenITKaravSEksiA
MEA 8.4.1
How much investment is necessary for private label manufacturing
In rodents there is high expression of GLP-1Rs in the calcitonin-producing C-cells of the thyroid, and activation of these receptors by GLP-1RAs stimulates the adenylate cyclase pathway, leading to upregulation of calcitonin synthesis and, subsequently, hyperplasia and an increased incidence of adenomas (88)
The brand-name versions, from drugmaker Novo Nordisk, sell for around $1,000 for a months supply
Their abstract begins: In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overw*ight or ob*sity, without diabetes. Already the veracity of the claims in this study is pulled into serious question