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This analysis revealed that 28 out of 48 genes (cluster 1), including Penk , Adora2a, Drd2 and Darpp32 , were highly enriched in iSPN + populations at 3 months and 8 months compared with the iSPN populations

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These findings are consistent with previous evidence suggesting that although GLP-1 receptor agonists improve lipid parameters, they are often insufficient to achieve guideline-recommended lipid targets without additional lipid-lowering therapy [21, 22]

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Severe bone loss