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However, general tissue healing research suggests applicability

In vivo , E2 treatment also activated estrogen signaling in inflammatory cells at the wound site during skin wound healing, a process that was inhibited in estrogen-deprived skin and restored upon estrogen application (Emmerson et al., 2013

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The Nrf2-ARE signaling pathway activates and enhances the expression of downstream antioxidant enzymes, serving as a critical cellular defense mechanism against oxidative stress (236)

There are certain cases where severe joint pain is reported