To model hospital outlier payments for the CY 2026 OPPS/ASC proposed rule, we applied the overall CCRs from the April 2025 OPSF after adjustment (using the proposed CCR inflation adjustment factor of 0.970113 to approximate CY 2026 CCRs) to charges on CY 2024 claims that were adjusted (using the proposed charge inflation factor of 1.1118 to approximate CY 2026 charges)
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In contrast, tirzepatide operates through a different biological mechanism
Pharmacokinetic modeling confirms this rapid onset with dose-dependent GH release (Agerso et al., 1999)
