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3 , 4 , 5 , 6 , 7 , 8 An immunohistochemical study in a RP pig model suggested that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidative damage

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See Cytochrome P450 Drug Interaction Table Sustained-release preparations (extended and modified-release formulations, more on this below )

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Maintenance Phase Period following loading where reduced dosing frequency maintains benefits without continued concentration building