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For apigenin, nanoformulations such as solid lipid and polymeric nanoparticles have enhanced stability, uptake, and antioxidant effects in metabolic models (88), while ellagic acid phytosome and nano-liposome formulations improved systemic exposure and insulin sensitivity in metabolic dysfunction models (90, 91)

Taken together, these data demonstrate the feasibility of Drosophila for the study of acetaminophen toxicity, bringing with it an ease of genetic and microbiome manipulation, high-throughput screening, and availability of transgenic animals

Moreover, p53 is known to be phosphorylated and consequently stabilized and activated by multiple signaling pathways, including ATM and MAPKs [79,80]

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2020) to accumulate in large quantities specifically in the DRG (Wei et al