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Acknowledgements We thank Lauren Knightley, Beth Jago, Meirion Richards, and Amin Mirza of the Structural Chemistry team for their expertise and assistance, Swen Hoelder for his continuous support, Stephen Hearnshaw for his contributions to crystal optimisation, and Chris Richardson for crystallography computing support

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These finding highlight the essential role of adiponectin in modulating microvascular inflammation and maintaining vascular homeostasis during sepsis

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