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Zhang et al., 2015

In clinical studies, the substance was applied 13 weekly for 412 weeks

Dihexa is a small peptide derived from angiotensin IV, and it works by activating the hepatocyte growth factor (HGF) pathway and its receptor c-Met, a mechanism that plays a critical role in the process of building new synapses

However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food

And thats not all

Common lengths for the types of injections we're discussing are 1/2 inch, 5/16 inch, and sometimes 1 inch or 1.5 inches for deeper applications