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Sources Jastreboff AM et al

However, Mounjaro (Tirzepatide) is already FDA-approved and proven to lower A1C effectively

B12 also supports energy metabolism during the caloric deficit created by tirzepatide

This requires a comprehensive assessment of the patients clinical characteristics, such as the duration of diabetes, presence of comorbidities, body mass index, and response to previous treatments

Conditions where obesity-driven inflammation significantly contributes to disease burden, such as rheumatoid arthritis, psoriatic arthritis, and psoriasis, are most likely to show indirect benefit from tirzepatide-induced weight loss

What The GLP1 + Exercise Trial Actually Showed In a JAMA trial, adults with obesity first went through an 8week lowcalorie diet, then moved into one of four paths for a year: exercise alone, a GLP1 drug alone (liraglutide), both together, or placebo