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In addition to a reduction of GPx3 levels, we also observed in our sibling cohort a large deficiency in cystine, the limiting factor to produce glutathione, which is required as a reducing agent for GPx3 and the entire glutathione peroxidase family 30,51

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Min HK, Kim SH, Choi JH, Choi K, Kim H-R, Lee S-H

Treatments counteracting oxidative stress, such as the antioxidant, N-acetylcysteine (NAC), have proven effective in preventing the emergence of behavioural and cognitive disruptions in various models of neurodevelopmental disorders [10, 41,42,43]