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While in most cases, the drug-induced kidney injury is reversible upon cease of treatment some medications could lead to chronic dysfunction such as papillary necrosis, tubulointerstitial nephritis, or prolonged proteinuria (Choudhury and Ahmed 2006)

In December of that year, the FDA placed a clinical hold on the program due to CMC issues and then in July 2021, the company scrapped it

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We next compared ICV versus intraperitoneal (IP) administration of mGIPR-Ab in diet-induced obese (DIO) mice