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Concerning amyloid and tau, the results were mixed: polyphenolic extract PEBG (500 or 2500 mg/kg, p.o., for 4 months) showed no significant effects on proteins like beta-secretase 1 and metalloproteinase domain 10 [21], whereas quercetin (80 mg/kg, p.o., for 21 days or 16 weeks) reduced cathepsin B and tau phosphorylation [35, 39]

A balanced approach to antioxidant use may enhance therapeutic efficacy while minimizing adverse effects

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The clinic integrates toxic burden assessment and metabolic profiling to address environmental and genetic factors (23:29) Patients are assumed magnesium deficient, often requiring detox support due to exposure to pesticides and endocrine disruptors

doi: 10.3389/fnins.2024.1342944

Over time, stress, environmental toxins, aging, and illness can deplete glutathione levels