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Overall, almost two decades since its discovery, ghrelin is now considered as one of the most important hormonal regulators of GH in vertebrates

Laboratory investigations explore how different types of senescent cells contribute to various aging phenotypes, while the peptide's selectivity enables researchers to test causal relationships between senescent cell burden and age-related functional decline

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Therefore, Class 1 peptides represent a locally-produced autocrine/paracrine form, and Class 2 peptides represent the circulating endocrine form in the body

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ROS activate a variety of hypertrophic signalling kinases and transcription factors, and lead to DNA/mtDNA damage and apoptosis (Tsutsui et al