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The liposomal delivery system in that 2016 study and Pickart's squalane approach are solving the same problem through different means: getting GHK-Cu where it needs to go

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Ensuring you are drinking enough water and getting adequate electrolytes can often help mitigate this

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Intranasal delivery, though less studied with Dihexa, would theoretically provide direct CNS access with minimal systemic exposure, potentially requiring the least frequent administration to maintain effective brain tissue concentrations