The landmark study is from 2025: Kuceki, Wambier, and colleagues published in JAAD International a trial using microneedling at 0.5 to 1.0 mm depth combined with a topical mixture of copper peptides, minoxidil 5%, and dutasteride 0.25%
The primary paper behind that line was retracted in April 2025
L., Wolin M
GHK-Cu peptide has been researched for its potential across a variety of functions (1) including that it may tighten and reverse the thinning of aging skin structure, supporting the extracellular matrix, that it may restore the skin barrier and moderate texture, hyperpigmentation and lesions, may support tissue repair and mitigate inflammation, may stimulate increasing hair follicle size, may exert antioxidant properties and, finally, may exhibit gene restructuring potential
Abnormal Calcium Homeostasis Calcium plays an integral role in numerous cell signaling pathways [137]
Levels of GHK-Cu may decline with age, and its presence in cosmetic formulations has drawn attention from those pursuing wellness-focused solutions
