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Dighriri, Khalid Hamed References 1.Obesity and overweight

10.1038/331354a0 Nature 337 TonosakiK.HoriY.ShimizuY.TonosakiK

When platelets are activated, the platelet skeleton membranes changes and they attach to the extracellular matrix and secrete chemokines and aggregate to others cells such leukocyte and endothelial cells leading to the formation of a plug 40

Orlistat (Xenical/Alli) blocks fat absorption in the gut

These cells are connected by tight junction proteins that regulate paracellular permeability the passage of molecules between cells rather than through them

Stores subcutaneous fat that provides insulation, cushions tissues and organs, and acts as an energy reserve