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Interrogation of specific cell-cell interactions using new tools such as bar-coded viral tracing technology, is beginning to identify specific molecular interactions, for example that Sema4d and EphrinB3 expressed by microglia control astrocyte responses respectively through PlexinB2 and EphB3 receptors

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Some forms of CKD have been linked to environmental nephrotoxins, such as exposure to heavy metals, mycotoxins produced by fungi in stored foods, air contaminants and pesticides

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