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Traditional tobacco (or ceremonial tobacco) holds important cultural and spiritual importance to most American Indian tribes and is used for prayer

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Furthermore, TR knockout in mice did not affect memory function following nicotine administration, confirming the role of TR in memory processes (75)

The quantity of NOX2-positive macrophages was elevated in the lungs of emphysema patients, and the elastase-induced emphysema and the high expression of ROS were prevented in NOX2-deficient mice

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