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Hair: Temporary hair shedding ( Telogen Effluvium ) due to rapid weight loss or nutritional deficiencies

A decrease in night-time growth hormone secretion is associated with reductions in lean body mass and muscle strength

Perez-Leighton, Butterick-Peterson, Billington, and Kotz (2013) proposed that throughout development of obesity, there are changes in orexinergic signaling, perhaps reducing orexinergic signaling gain by changes in synaptic plasticity, which continue to change orexin system responsiveness and promote further development of obesity

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