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Someone already eating moderately may need 46 weeks to notice scale changes

Dopamine modulates the reward and the "pleasure" feeling of food

doi:10.3389/fneur.2011.00087 Liu ZQ, Li XX, Qiu SQ, et al

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Benjamin Scirica, one of the trial investigators, noted that most cardiovascular drugs, such as statins, focus on reducing cardiovascular-related deaths, but they do not usually impact non-cardiovascular deaths