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If you are taking Methotrexate for psoriasis or psoriatic arthritis, you should notice a decrease in skin- and joint-related symptoms within four to six weeks

Wong MC, Ng BK, Tian I, Sobhiyeh S, Pagano I, Dechenaud M, et al

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It should be taken at least 2 hours apart from antibiotic treatment , as it may affect the drugs absorption