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Third, while exposure to SGLT2 inhibitors and DPP-4 inhibitors was excluded in the GLP-1 RA group, the potential effects of other antidiabetic medications could not be fully eliminated and may have influenced outcome assessment

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As agonist dissociation within endosomes is a determinant of post-endocytic targeting to recycling or degradative pathways 44 , these observations may explain the contrasting recycling patterns of exendin-phe1 vs

3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers