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During ER stress, GRP78, the primary regulator of UPR, dissociates from the ER compartment, activating the main PERK protein pathway

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Using anaerobic incubation and a gnotobiotic mouse model, we confirmed the role of these microbes in TMA/TMAO production

Had you waited through the transition (usually one to two weeks), the spike would have resolved and you would have settled into a comfortable steady state at 7.5 mg