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Thus, they may have a different effect on the activity of the HPA axis in humans

Moreover, despite more semaglutide-treated patients starting at doses higher than the minimal dose and reaching the higher approved maintenance doses (i.e., 10 mg for tirzepatide and 1.7 mg for semaglutide) during follow-up, weight reduction remained greater in the tirzepatide group

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As body weight decreases, the body's overall energy expenditure naturally declines because there is less tissue to maintain