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Abnormal apoptosis is associated with many human diseases and external influences, such as ischemic injury, autoimmune diseases and cancer

PMID 25499849

Biomedicine 40:119122

Small amounts of ROS are produced from endothelial NADP (H) oxidase activated by growth factors and cytokines

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For instance, genetic studies have identified atypical SNPs regulating the Gln-Glu cycle [14], and postmortem analyses have shown a lower expression of enzymes involved in the cycle [15]