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Sirtuins (SIRTs) are a protein family with versatile functions, such as metabolic control, epigenetic modification and lifespan extension [31]

Unlike pattern baldness, this represents physical injury rather than biological process

P values were considered significant at 0.05, 0.01, and 0.001 levels

In addition, FOXO4-related peptide inhibits the interaction of p53 with FOXO4 to promote p53-medicated apoptosis [10], and the HSP90 inhibitor 17-DMAG impacts the anti-apoptotic PI3K/AKT pathway [11]

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