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Nature clinical practice Endocrinology & metabolism

Mild to severe liver disease may be found, and the liver is frequently palpable regardless of the coexistence of heart failure (392)

49 A deficit in the tricarboxylic acid cycle and ETC function under conditions of excessive superoxide production in the brain would be expected to result in a reduced ability to maintain adequate levels of ATP required for normal neuronal and synaptic functioning

This means that if you got your test a few years ago, it probably wont effectively detect the presence of drugs anymore

Nonetheless, its utility in cancer and aging studies makes it indispensable for precise lesion quantification