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For example, research has shown doses ranging from 2501,250 mg per day to to be effective for different conditions

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This association with iron accumulation in chondrocytes is characterized by IL-1 upregulating TfR1 and DMT1 while downregulating FPN1, which exacerbates iron overload, disrupts ECM balance, and ultimately leads to cartilage damage ( In recent years, the roles of oxidative stress and mitochondrial dysfunction in the progression of OA have garnered significant attention (Suantawee et al., 2013

Thus, Quer, as an activator of the GSH system, is a promising natural small molecule for the treatment of cardiac injury

Similarly, by upregulating GPX4 and SLC7A11 expression in chondrocytes, baicalein, an extract from scutellaria baicalensis, has been shown to prevent ferroptosis and postpone the development of OA [99]