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Studies comparing delivery methods show topical formulations achieve only a fraction of the bioavailability that subcutaneous injection provides

But with that popularity comes the question: what to expect if your patients have to stop the medication

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Abbreviations CV: Cardiovascular DMO: Diabetic macular oedema EMR: Electronic medical record GLP1-ra: Glucagon-like peptide 1 receptor agonist HCO: Healthcare organisation HF: Heart failure ICD-10-CM: ICD, Tenth Revision, Clinical Modification SGLT2: Sodiumglucose cotransporter 2 SGLT2i: Sodiumglucose cotransporter 2 inhibitor VEGF: Vascular endothelial growth factor References Saeedi P, Petersohn I, Salpea P et al (2019) Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

Tocopherol (Vitamin E) : Antioxidant protection

That's the standard we should be building toward