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By intersecting the above 15 candidates with the differentially expressed miRNAs of folic acid-induced kidney injury and fibrosis (GSE61382), and unilateral ureteral obstruction (UUO) (GSE118340), we identified two potential targets: mmu-miR-27-5p and mmu-miR-93-3p (Fig

All GLP-1 agonists caused reduced fetal growth and decreased weight when used during late gestation and lactation

Other insulin-dependent mechanisms contributing to PBH include decreased pancreatic -cell suppression in response to hypoglycemia and reduced insulin clearance

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Clinical trials and meta-analyses indicate that berberine significantly reduces total cholesterol, LDL, and triglycerides (while raising HDL) in patients with dyslipidemia, an effect partly due to upregulation of LDL receptor expression in the liver and modulation of AMPK-dependent lipid metabolism

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