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Although over 2000 different mutations in the p53 gene have been reported in human cancers [84], most mutations occur at six hotspot amino acid residues in the DNA-binding domain (R175, G245, R248, R249, R273 and R282) [85]

ISBN 978-1-56025-427-0

This ones a bit tricky because normal varies for everyone

Morbidity and Mortality Weekly Report , 67(SS12), 142

The evidence from the policy research will be useful in countering tobacco industry challenges to future reforms in graphic health warnings and plain packaging proposals in the Philippines (28)

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