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Many of those local laws require tobacco products to be placed behind the counter, forcing customers to ask for specific items before making purchases

The Piedmont Triad of Greensboro, Winston-Salem, and High Point lies further west

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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30