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3 Psychological symptoms of nicotine withdrawal include: Strong cravings for nicotine Increased anxiety Difficulties with concentration Insomnia or other sleep problems Restlessness Depression symptoms Physical symptoms of nicotine withdrawal include: Headaches Sore throat Coughing Constipation or other gastrointestinal distress Increased heart rate Breathing problems Fatigue Increased appetite Dizziness Timeline Of Nicotine Withdrawal The symptoms of nicotine withdrawal tend to be strongest during the first 24-72 hours after last using nicotine