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Biochemistry 2009

Further underscoring the gut-brain axis significance, a study revealed that patient-derived -synuclein aggregates are capable of inducing both nigrostriatal alterations and ENS pathology following either intestinal or striatal injection in non-human primates [125]

Over-representation analysis (ORA), analysis of functional networks of protein-protein interactions, transcript cluster analysis, and correlations were performed (see SI and Results for details)

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44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops