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3 Results 3.1 Epidemiology Recent national surveys among Italian adolescents aged 1315 years were prioritized in this review because they provide high-quality, nationally representative data within a well-defined regulatory framework, allowing for a clear interpretation of trends in youth tobacco and e-cigarette use ( Multiple factors contribute to the growing popularity of e-cigarettes among youth (Table 1)

Originating from South Korea, Esse quickly gained popularity in various international markets, especially among younger adults and women who appreciate its sleek look and lighter smoking profile

Mast cells degranulate and produce bradykinin, which activates nociceptors

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