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African Red - Tobacco This upright variety produces up to 28 glossy leaves with a strong fragrance and high nicotine content: 29.8 mg per gram of dry leaf

Mycologia 113, 212230

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Too Dry : It crumbles easily, feels crisp or brittle, and wont spring back Too Wet : It sticks together, clumps, and may feel damp to the touch

Other systemic toxicity A meta-analysis of four in vivo studies conducted by PMI researchers assessed the impact of IQOS on the activity of the cytochrome P450 1 A2 (CYP1A2) enzyme responsible for the metabolism of harmful xenobiotics like amines