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The history of the discovery of the cigarette-lung cancer link: Evidentiary traditions, corporate denial, global toll

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Importantly, if the harm reduction potential of a HTP is to be maximised, reduced exposure must be allied with HTP uptake by sufficient numbers of adult smokers who would otherwise continue to smoke cigarettes

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Similar findings were observed in a cross-sectional study, where healthy young e-cigarette users showed increased oxidative stress in circulating immune cells, indicating a future risk of cardiovascular diseases [54]

The DNMT3 family of DNA methyltransferases has three members: DNMT3A, DNMT3B, and DNMT3L