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Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: An updated systematic review and meta-analysis including the latest SURMOUNT-2 trial

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[14] Maximal secretion of GH may occur within minutes of the onset of slow-wave (SW) sleep (stage III or IV)

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[8] Among licensed oral options: Orlistat the most widely used oral weight loss medicine in the UK produces average weight loss of approximately 35% of body weight over 12 months when combined with dietary changes, though some individuals achieve greater reductions