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Under physiological conditions, Nrf2 is sequestered in the cytoplasm by Keap1, which facilitates its ubiquitination and proteasomic degradation
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In 2020, researchers They studied 52 people aged 18 to 45
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Thus, mutational signatures can offer unique information that is distinct from that of molecular drivers and gene expression and investigating the relationship between mutational signatures and LCNS evolution may allow for better patient management in the future
Figure 2.3 Cancer cells spread to the entire body
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