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In order to prevent mitochondrial malfunction and sustain metabolic function/energy generation (ATP), NAD+ supplementation may counterbalance the age-related degradation of NAD+ and its precursor nicotinamide mononucleotide by NADases, particularly CD38.7 NAD+ replenishment, however, appears to support a number of other metabolic pathways via NAD+-dependent enzymes in research involving human and animal models (as well as samples and cell lines) (1,2,3)

It helps regenerate both glutathione and Vitamin C, making the entire antioxidant network more efficient

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doi: 10.1016/j.neubiorev.2017.03.003 184 GoldsmithDRRapaportMHMillerBJ

On the other hand, if your glutathione levels are low, your body might be more open to damage, and you might feel tired or get sick more easily

Glutathione is susceptible to oxidation, and exposure to light, heat, and air can degrade the active compound before you even open the bottle