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and (3) identify limitations, safety considerations, and research gaps for future investigation

Elucidation of its pharmacological mechanism through molecular docking suggested luteolin as one of three main active components closely related to asthma, specifically the IL-17 inflammatory pathway [158]

Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

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235,360,361 Another hypothesis is that hepatocytes undergo a transient epithelialmesenchymal transition to escape the suppressive effects of elevated TGF- levels